Aimee Mayo grew up in Gadsden, Alabama. According to her mother, Aimee always had a notebook with her and was constantly writing poetry. Her mother encouraged her to "shoot for the top" and she was signed as a songwriter with BMG while she was still a teenager. It was there that she met her husband, Chris Lindsey, a fellow songwriter. She and Chris have three children and live in Nashville, Tennessee.
As a teen, Aimee was surrounded by music. Her father Danny Mayo wrote hits for numerous country artists. Her brother Cory Mayo wrote You'll Be There, a hit for George Strait in 2005.
Mayo was named BMI Songwriter of the Year in 2000. "Amazed," recorded by Lonestar that same year, is her most popular song to date. In 2004 it garnered a 5 Millionaire award from BMI, vaulting it into the top 125 songs in the BMI catalog out of 6.5 million works. “Amazed” also won ACM (Academy of Country Music) Song of the Year, BMI Song of the Year, NSAI Song of the Year and was nominated for a Grammy. “Amazed” crossed over to the pop charts and spent two weeks at the top of the Hot 100, making it the first country song to accomplish such a feat since Dolly Parton and Kenny Rogers with their 1983 song “Islands in the Stream.”
Mayo's song “This One’s for the Girls,” recorded by Martina McBride, stayed at #1 on Billboard's Adult Contemporary chart for eleven weeks in addition to reaching number three on the country chart. The song also went on to be a theme song for the morning show “The View.” Mayo has received over a dozen BMI Country awards along with BMI Pop Awards for “Amazed” and “This One’s For the Girls.”
Mayo co-wrote the song "Wheel of the World" on Carrie Underwood’s second album with husband Chris Lindsey and close friend and collaborator Hillary Lindsey. The title “Carnival Ride” was chosen by Underwood from the lyrics of “Wheel of the World.”
Mayo was a judge on the CMT television series, "Can You Duet".